C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/7088 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2742531
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR5. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR5 expression and for prevention or treatment of diseases wherein modulation of TLR5 expression would be beneficial are provided.
L'invention porte sur des composés oligonucléotidiques antisens, sur des compositions et des procédés de régulation négative de l'expression de TLR5. Les compositions comprennent des oligonucléotides antisens ciblés vers des acides nucléiques codant pour TLR5. Les compositions peuvent également comprendre des oligonucléotides antisens ciblés vers des acides nucléiques codant pour TLR5 en combinaison avec d'autres composés et/ou compositions thérapeutiques et/ou prophylactiques. L'invention porte également sur des procédés d'utilisation de ces composés et de ces compositions pour réguler négativement l'expression de TLR5 et pour prévenir ou traiter des maladies dans lesquelles la modulation de l'expression de TLR5 serait utile.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar
Putta Mallikarjuna
Wang Daqing
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Idera Pharmaceuticals Inc.
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