Modulators of 5-ht receptors and methods of use thereof

Details Modulators of 5-ht receptors and methods of use thereof Modulators of 5-ht receptors and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/551 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01) A61P 25/00 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2761961

The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

La présente invention concerne une décahydropyrroloazépine à fusions aryle et hétéroaryle, un octahydro-oxépinopyrrole, un dioxyde d'octahydro-pyrrolothiazépine, un décahydro-cyclohepta[c]pyrrole, et des dérivés d'octahydro-cyclohepta[c]pyrrole représentés par la formule (I) dans laquelle R1,R2, R3, R4, R5, A, Y1, Y2, et Y3 sont tels que définis dans les spécifications. L'invention concerne également des compositions comprenant de tels composés, des procédés permettant de fabriquer de tels composés, des procédés permettant de traiter des états pathologiques au moyen de tels composés et compositions, et des procédés permettant d'identifier de tels composés.

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