Modulators of chemokine receptor activity

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2440803

Chemokine receptor antagonists, in particular, bicyclic diamine compounds of Formula (1) that act as antagonists of chemokien CCR2 and CCR3 receptors including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leucocyte accumulation are described herein.

L'invention concerne des antagonistes du récepteur de la chimiokine en particulier des composants diamine bicycliques de formule (1) agissant comme des antagonistes des récepteurs CCR2 et CCR3 de la chimiokine comprenant des préparations pharmaceutiques et des utilisations de celles-ci afin de traiter ou prévenir des maladies associées à l'accumulation de monocytes, de lymphocytes ou de leucocytes.

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