Modulators of interleukin-1 receptor-associated kinase

Details Modulators of interleukin-1 receptor-associated kinase Modulators of interleukin-1 receptor-associated kinase

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01)

Patent

CA 2663091

The present invention relates to modulators of IRAK kinase and provides compositions comprising such modulators, as well as methods therewith for treating conditions or diseases mediated by or associated with IRAK kinase, such as rheumatoid arthitis, multiple sclerosis, sepsis, osteoarthrites, inflammatory bowel disease, osteoporosis, myasthenia gravis, stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, psoriasis, cardiac contractile dysfunction, type I diabetes, type II diabetes, familial cold autoinf lammatory syndrome, severe bacterial infections, allergic disease, cancer, psoriasis, asthma, or graft rejection.

La présente invention concerne des modulateurs de la kinase IRAK (Interleukin-1 Receptor-Associated Kinase) et des compositions comprenant de tels modulateurs, ainsi que des procédés permettant de traiter des affections ou des maladies induites par la kinase IRAK ou associées à la kinase IRAK.

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