Modulators of protein tyrosine phosphatases

Details Modulators of protein tyrosine phosphatases Modulators of protein tyrosine phosphatases

C - Chemistry, Metallurgy

07

C

C07C 235/84 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) C07D 209/18 (2006.01) C07D 213/55 (2006.01) C07D 239/28 (2006.01) C07D 241/24 (2006.01) C07D 333/62 (2006.01) C07D 497/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2323472

The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTP.alpha., PTP.epsilon., PTPµ, PTP.delta., PTP.sigma., PTP, PTP.beta., PTPD1, PTPD2, PTPH1, PTP- MEG1, PTP-LAR, and HePTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes.

Cette invention se rapporte à de nouveaux composés, à de nouvelles compositions, à des procédés pour leur utilisation et à des procédés pour leur fabrication, ces composés constituant des inhibiteurs pharmacologiquement utiles des protéine-tyrosine-phosphatases (PTPases, PTP) telles que PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTP.alpha., PTP.epsilon., PTPµ, PTP.delta., PTP.sigma., PTP?, PTP.beta., PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR ET HePTP. Ces composés sont indiqués dans la prise en charge ou le traitement d'une large gamme de maladies, telles que les maladies auto-immunes, les inflammations aiguës et chroniques, l'ostéoporose, diverses formes de cancer et d'affections malignes, ainsi que le diabète de type I et le diabète de type II.

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