C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2421265
The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.
L'invention concerne des polynucléotides humains purifiés utilisés à des fins diagnostiques et thérapeutiques (dithp). Elle concerne également les polypeptides (DITHP) codés par ces dithp, ainsi qu'à l'utilisation de ces dithp, ou de leurs compléments, oligonucléotides ou fragments dans des analyses diagnostiques. L'invention concerne en outre des vecteurs et cellules hôtes contenant ces dithp et permettant l'expression de DITHP, ainsi que l'utilisation de tels DITHP isolés et purifiés pour induire des anticorps et pour analyser des banques de composés, et l'utilisation des anticorps anti-DITHP dans des analyses diagnostiques. L'invention concerne enfin des micro-ensembles contenant des dithp et leur procédés d'utilisation.
Altus Christina M.
Au Alan P.
Bradley Diana L.
Chalup Michael S.
Chang Simon C.
Altus Christina M.
Au Alan P.
Bradley Diana L.
Chalup Michael S.
Chang Simon C.
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