Molecules for diagnostics and therapeutics

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/16 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2434677

The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP .The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.

La présente invention concerne des polynucléotides humains purifiés utilisés à des fins diagnostiques et thérapeutiques (dithp). Elle concerne également des polypeptides (DITHP) codés par les dithp. De plus, l'invention concerne l'utilisation de dithp, ou de compléments de dithp, d'oligonucléotides ou de fragments d'oligonucléotide , pour des analyses diagnostiques. L'invention concerne en outre des vecteurs et des cellules hôtes renfermant des dithp pour l'expression de DITHP .Par ailleurs, cette invention porte sur l'emploi de DITHP isolés et purifiés dans le but de produire des anticorps anti-DITHP dans des tests de diagnostic. L'invention concerne enfin des microréseaux renfermant des dithp et leurs modes d'utilisation.

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