Molecules for diagnostics and therapeutics

Details Molecules for diagnostics and therapeutics Molecules for diagnostics and therapeutics

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2385496

The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.

L'invention concerne des polynucléotides humains purifiés pour le diagnostic et la thérapeutique (dithp). Elle porte encore sur les polypeptides (DITHP) codés par dithp, ainsi que sur l'utilisation de dithp, de compléments, d'oligonucléotides ou de fragments de ceux-ci dans des analyses diagnostiques. L'invention se rapporte encore à des vecteurs et à des cellules hôtes contenant dithp, pour l'expression de DITHP, ainsi qu'à l'utilisation de DITHP isolés et purifiés pour l'induction d'anticorps et pour le criblage de banques de composés, et à l'utilisation d'anticorps anti-DITHP dans des analyses diagnostiques. Des jeux ordonnés de microéchantillons contenant dithp et leurs procédés d'utilisation sont également décrits.

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