Molecules for disease detection and treatment

Details Molecules for disease detection and treatment Molecules for disease detection and treatment

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2374822

The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.

L'invention concerne des polynucléotides (mddt.) purifiés de molécules de traitement et de détection de maladies. Elle porte également sur les polypeptides (MDDT) codés par mddt ainsi que sur l'utilisation de mddt, de compléments, d'oliugonucléotides ou de fragments de ceux-ci, dans des analyses diagnostiques. Elle se rapporte encore à des vecteurs et à des cellules hôtes contenant mddt, pour l'expression de MDDT. Elle concerne enfin l'utilisation de MDDT isolé et purifié, pour l'induction d'anticorps et pour le criblage de banques de composés ainsi que l'utilisation d'anticorps anti-MDDT dans des analyses diagnostiques. Des jeux ordonnés de microéchantillons de mddt ainsi que leurs procédés d'utilisation sont également décrits.

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