Monoclonal antibodies against .beta.3 integrins

Details Monoclonal antibodies against .beta.3 integrins Monoclonal antibodies against .beta.3 integrins

C - Chemistry, Metallurgy

12

N

C12N 5/16 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2628900

Monoclonal antibodies prepared against platelet .beta.3 integrin useful in antithrombotic therapy or in models of thrombosis, thrombocytopenia, and anti-angiogenesis. The antibodies are prepared using .beta.3 integrin deficient (.beta.3-/-) mice immunized against platelets or .beta.3 integrin fragments.

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