Monoclonal antibodies and fv specific for cd2 antigen

Details Monoclonal antibodies and fv specific for cd2 antigen Monoclonal antibodies and fv specific for cd2 antigen

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2124126

An anti-CD2 monoclonal antibody according to the present invention can be: (1) a chimeric monoclonal antibody CD2 SFv-Ig produced by expression of the construct cloned in recombinant Escherichia coli culture ATCC No. 69277; (2) a monoclonal antibody having complementarity-determining regions identical with those of CD2 SFv-Ig; or (3) a monoclonal antibody competing with CD2 SFv-Ig for binding to CD2 antigen at least about 80% as effectively on a molar basis as CD2 SFv-Ig. Anti--CD2 monoclonal antibodies according to the present invention, as well as other antibodies that can modulate the interactions between T lymphocytes and monocytes, can be used to inhibit the production of HIV-1 by HIV-1--infected T cells in HIV-1-infected patients. In another use, T cells treated in vitro can be reinfused into AIDS patients to increase the proportion of functional, non--HIV-1-producing T cells in the patient.

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