Monofluoroalkyl derivatives

Details Monofluoroalkyl derivatives Monofluoroalkyl derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/03 (2006.01) A61K 31/18 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) C07C 307/06 (2006.01) C07C 311/04 (2006.01) C07C 311/05 (2006.01) C07C 311/06 (2006.01) C07C 311/08 (2006.01) C07C 311/37 (2006.01) C07C 311/39 (2006.01) C07D 209/34 (2006.01) C07D 213/38 (2006.01) C07D 213/61 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 261/18 (2006.01) C07D 295/192 (2006.01) C07D 333/20 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2372490

The present invention provides monofluoroalkyl derivatives of the formula (I) wherein: A represents SO2, CO2 or CONH; Ra represents (1-6C)alkyl, (2- 6C)alkenyl, -(1-4C)alkyl(3-8C)cycloalkyl, or (1-4C)alkylaromatic; Rb represents H, (1-6C)alkyl, (2-6C)alkenyl, -(1-4C)alkyl(3-8C)cycloalkyl, or (1- 4C)alkylaromatic; or Ra and Rb together with the carbon atoms to which they are attached form a (3-8C) saturated carbocyclic ring, a (3-8C) saturated carbocyclic ring containing a heteroatom selected from the group consisting of sulfur or oxygen, or a (5-8C) carbocyclic ring containing one double bond; R1 represents an unsubstituted or substituted aromatic group, an unsubstituted or substituted heteroaromatic group, or an unsubstituted or substituted (5- 8C)cycloalkyl group; R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1- 6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1- 4C)alkoxy, or when A represents SO2, a group of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or , together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; or a pharmaceutically acceptable salt thereof, useful for potentiating glutamate receptor function in a mammal and thereof, useful for treating a wide variety of condutions, such as psychiatric and neurological disorder.

La présente invention concerne certains dérivés de monofluoralkyle utiles pour potentialiser la fonction des récepteurs de glutamate chez un mammifère et, partant, pour traiter toute une gamme d'états tels que des troubles psychiatriques et neurologiques.

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