Monomeric and dimeric antibody-fragment fusion proteins

Details Monomeric and dimeric antibody-fragment fusion proteins Monomeric and dimeric antibody-fragment fusion proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 9/00 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2128511

The present invention describes a new class of antigen binding molecules which contain Fv-fragments of an antibody but do not use the constant antibody domains. They can also dimerize with other antibody fragment molecules or with non-antibody fragment molecules to form bi- or multifunctional antibody-fragment fusion proteins and so-called miniantibodies, respectively. The new fusion proteins can be used in the broad field of diagnostic and therapeutical medicine.

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