C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01) G01N 33/534 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2416544
The present invention is to µ-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the µ-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The µ-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the µ-conopeptides and encoding propeptides, as well as the propeptides.
L'invention porte sur les conopeptides µ, leurs dérives ou leurs sels pharmacocompatibles, et sur l'utilisation de ces peptides, de leurs dérives ou de leurs sels pharmacocompatibles pour le traitement de troubles associés aux canaux sodiques tensiodépendants. Lesdits conopeptides µ ou leurs dérives s'avèrent donc utiles comme agents de blocage neuromusculaire, comme anesthésiques, comme analgésiques, et comme agents neuroprotecteurs. Les conopeptides µ peuvent également traiter les troubles neuromusculaires. L'invention porte en outre sur des séquences d'acides nucléiques codant pour les conopeptides µ et leurs propeptides, et sur ces mêmes propeptides.
Cartier G. Edward
Cruz Lourdes J.
Garrett James E.
Jacobsen Richard B.
Jones Robert M.
Cognetix Inc.
Gowling Lafleur Henderson Llp
University Of Utah Research Foundation
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