C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61P 3/00 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07K 14/775 (2006.01) C12N 15/11 (2006.01) C12Q 1/18 (2006.01) C12Q 1/60 (2006.01) C12Q 1/61 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2584048
Disclosed herein are peptides or peptide analogs with multiple amphipathic .alpha.-helical domains that promote lipid efflux from cells via an ABCAl- dependent pathway. Also provided herein are methods of using multi-domain amphipathic .alpha.-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
L'invention porte sur des peptides ou sur des analogues peptidiques possédant plusieurs domaines alpha-hélicoïdaux amphipathiques qui facilitent la sortie des lipides des cellules par un passage dépendant d'ABCA1. L'invention porte également sur des méthodes d'utilisation des peptides alpha-hélicoïdaux amphipathiques à plusieurs domaines ou des analogues peptidiques pour traiter ou inhiber des troubles dyslipidémiques. L'invention porte également sur des méthodes d'identification des peptides non cytotoxiques qui facilitent la sortie des lipides dépendant d'ABCA1 provenant des cellules.
Amar Marcele J. A.
Bryan Brewer H.
Demosky Stephen J.
Neufeld Edward B.
Remaley Alan T.
Smart & Biggar
The Government Of The United States Of America As Represented By
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