Multicistronic sirna constructs to inhibit tumors

Details Multicistronic sirna constructs to inhibit tumors Multicistronic sirna constructs to inhibit tumors

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01)

Patent

CA 2587854

Multicistronic short interfering RNA constructs targeting in various combinations a human urokinase-type plasminogen activator receptor (uPAR), human urokinase-type plasminogen activator (uPA), human matrix metalloprotease 9 (MMP-9) and cathepsin B (CB) inhibit tumors.

L'invention concerne des constructions d'ARN interférants courts multicistroniques ciblant dans plusieurs combinaisons un récepteur humain des activateurs du plasminogène du type urokinase (uPAR), l'activateur humain du plasminogène du type urokinase (uPA), la métalloprotéase matricielle 9 humaine (MMP-9) et la cathepsine B (CB), ces constructions d'ARN interférants inhibant les tumeurs.

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