Multilamellar liposomal arachidonic acid metabolite...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/557 (2006.01) A61K 9/127 (2006.01) A61K 31/5575 (2006.01)

Patent

CA 2175057

This invention provides a multilamellar liposome containing an arachidonic acid metabolite, two or more lipid-containing bilayers and two or more aqueous compartments containing a release-inhibiting buffer. Preferred arachidonic acid metabolites are the prostaglandins, particularly PGE1. The liposomal formulations can be used to treat animals, particularly humans, for diseases, disorders or conditions which can be ameliorated by prostaglandins, e.g. disorders characterized by cellular activation and ahesion, inflammation and/or toxemia.

L'invention concerne un liposome multilamellaire contenant un métabolite d'acide arachidomique, deux membranes ou plus à deux couches contenant des lipides et deux compartiments aqueux ou plus contenant un tampon inhibiteur de libération. Les métabolites d'acide arachidonique préférés sont les prostaglandines, particulièrement PGE¿1?. On peut utiliser les formulations liposomiques pour traiter l'animal et l'homme en particulier, contre des maladies, des dysfonctionnements ou des états pouvant être traités au moyen des prostaglandines, par exemple, des troubles caractérisés par une activation et par une adhésion cellulaires, l'inflammation et/ou la toxémie.

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