C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/33 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2645740
The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions man be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition.
L'invention concerne une toxine clostridiale multivalente comprenant au moins un domaine de liaison à une molécule de surface cellulaire d'une cellule cible. Ces toxines modifiées servent de compositions thérapeutiques pour prévenir une exocytose et une sécrétion de la cellule cible. Les états pathologiques pour lesquels ces compositions sont utiles comprennent, de manière non exhaustive, des troubles du système sensoriel ou du système nerveux moteur, des douleurs aiguës ou chroniques, le cancer, la pancréatite, l'hyperhydrose, des troubles adénoïdes, des infections virales, la fibrose kystique et analogues. L'invention concerne également des procédés d'utilisation et d'administration d'une telle composition et des procédés permettant de traiter un trouble donné à l'aide de la composition de l'invention.
Aoki Kei Roger
Fernandez-Salas Ester
Francis Joseph
Gilmore Marcella A.
Li Shengwen
Allergan Inc.
Gowling Lafleur Henderson Llp
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