C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/18 (2006.01) A61K 31/404 (2006.01) A61P 3/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2627043
Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase- related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds of the invention consist of linked indole derivatives having at ' least two bicyclic rings of formula FIG. 6C in which R1R7 are defined as in claim 1 and in which the fused five membered ring contains a nitrogen atom and the fused six membered ring optionally contains one or two nitrogen atoms. The two or more bicyclic rings of Figure 6c are joined by a multifunctional bridge moiety substituted by two or more linking groups L which are joined to the bicyclic ring.
L'invention concerne de l'indole et des composés apparentés à l'indole, des compositions et des méthodes. Les composés de l'invention sont utiles en tant qu'inhibiteurs de phospholipases. Les composés et compositions de l'invention sont utiles pour le traitement d'états liés aux phospholipases, tels que les états liés à l'insuline, liés au poids et/ou liés au cholestérol chez un sujet animal.
Buysse Jerry M.
Cartigny Damien
Chang Han-Ting
Charmot Dominique
Chen Shiah-Yun
Ilypsa Inc.
Ridout & Maybee Llp
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