Muscarinic receptor antagonists

Details Muscarinic receptor antagonists Muscarinic receptor antagonists

C - Chemistry, Metallurgy

07

C

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C07C 237/20 (2006.01) C07C 237/24 (2006.01) C07C 255/42 (2006.01) C07C 255/47 (2006.01) C07C 255/58 (2006.01) C07C 311/08 (2006.01) C07D 213/38 (2006.01) C07D 213/56 (2006.01) C07D 307/79 (2006.01) C07D 307/81 (2006.01) C07D 317/58 (2006.01) C07D 319/16 (2006.01)

Patent

CA 1338416

A compound of the formula (IA) or (IB), useful in treating diseases associated with the altered motility and/or tone of smooth muscle, such as irritable bowel syndrome, of the formula:- Image or Image (IA) (IB) and their pharmaceutically-acceptable salts, where Y is -CH2CH2-, -CH=CH-, -CH2-S-, -CH2-O-, -C- or -S-; and X is a group of the formula:- Image wherein m is 1 or 2; R1 and R2 are each independently H or C1-C4 alkyl or together represent -(CH2)n- where n is an integer of from 2 to 5; R3 is H or C1-C4 alkyl; Z is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-; and R4 is pyridyl, pyrazinyl, thienyl or a group of the formula:- Image where either R5 and R6 are each independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, halo, -CF3, -CN, -(CH2)pNR7R8 , -OCO(C1-C4 alkyl), -CO(C1-C4 alkyl), -CH(OH)(C1-C4 alkyl), -C(OH)(C1-C4 alkyl)2, -SO2NH2, -NHSO2(C1-C4 alkyl), -(CH2)pOH, -(CH2)pCOO(C1-C4 alkyl), -(CH2)pCONR7R8, or R5 and R6 together represent -(CH2)q-, -O(CH2)rO- or -O(CH2)t- where in the latter the oxygen atom is attached to the 3- or 4-position of the benzene ring; R7 and R8 are each independently H or C1-C4 alkyl; p is 0, 1 or 2; q is 3, 4 or 5; r is 1, 2 or 3; and t is 2, 3 or 4.

612266

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