Mutations responsible for attenuation in measles virus or...

Details Mutations responsible for attenuation in measles virus or... Mutations responsible for attenuation in measles virus or...

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/165 (2006.01) C07K 14/12 (2006.01) C07K 14/135 (2006.01)

Patent

CA 2323927

Isolated, recombinantly-generated, attenuated measles viruses and respiratory syncytial subgroup B viruses having defined attenuating mutations are described. Vaccines are formulated comprising such viruses and a physiologically acceptable carrier. The vaccines are used for immunizing an individual to induce protection against measles virus or respiratory syncytial subgroup B virus.

L'invention concerne le virus de la rougeole et le virus respiratoire syncytial humain du sous-groupe B, ces virus étant isolés, générés par recombinaison et atténués et présentant des mutations d'atténuation définies. L'invention concerne également des formulations de vaccins comprenant ces virus et un excipient physiologiquement acceptable. Les vaccins s'utilisent pour immuniser un individu et le protéger contre le virus de la rougeole ou le virus respiratoire syncytial humain du sous-groupe B.

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