C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) A61K 31/5383 (2006.01) A61P 31/04 (2006.01) C07D 451/04 (2006.01) C07D 471/04 (2006.01) C07D 498/06 (2006.01)
Patent
CA 2688008
[PROBLEMS] To provide a novel mutilin derivative substituted at the 14-position which shows a potent and broad antibacterial function on gram-positive bacteria and gram-negative bacteria including various drug-resistant bacteria and is expected as useful as a remedy for infectious diseases. [MEANS FOR SOLVING PROBLEMS] A mutilin derivative represented by the following general formula (1) or a pharmaceutically acceptable addition salt of the same.
L'invention vise à proposer un nouveau dérivé de la mutiline substitué à la position 14, qui présente une fonction antibactérienne puissante et large sur des bactéries gram positives et des bactéries gram négatives, comprenant diverses bactéries résistant aux médicaments et est attendue être utile en tant que remède pour des maladies infectieuses. A cet effet, l'invention concerne un dérivé de la mutiline représenté par la formule générale suivante (1) ou un sel d'addition pharmaceutiquement acceptable de celui-ci.
Asahina Yoshikazu
Ebisu Hiroyuki
Fukuda Hideyuki
Fukuda Yasumichi
Kurasaki Haruaki
Kyorin Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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