N-acylpiperazine derivative, antibacterial drug, and...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/182 (2006.01) A61K 31/495 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01) C07D 317/68 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2172913

An N-acylpiperazine derivative or a salt thereof in accordance with the present invention is represented by the following formula 1: wherein R1 represents a lower alkyl, hydroxy lower alkyl, lower acyl, or arylcarbonyloxy lower alkyl group; R2 represents hydrogen atom or a lower alkyl, lower alkoxy, lower alkenyl, amino, or nitro group; R3 and R4, which are identical to or different from each other, represent hydrogen atoms, halogen atoms, or cyano, nitro, lower alkyl, or lower alkoxy groups; and n represents 0 or 1. The N-acylpiperazine derivative has anti-ulcer effect or an antibacterial activity against Helicobacter pyroli to be available for prevention or cure of ulsers.

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