N-alkylated peptides having antiangiogenic activity

Details N-alkylated peptides having antiangiogenic activity N-alkylated peptides having antiangiogenic activity

C - Chemistry, Metallurgy

07

K

C07K 14/78 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2386893

N-Alkylated peptides of the formula (I) Xaa1- Xaa2- Xaa3- Xaa4- Xaa5- Xaa6- Xaa7- Xaa8- Xaa9- Xaa10- Xaa11-, are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

L'invention concerne des peptides N-alkylatés de formule (I) Xaa¿1?- Xaa¿2?- Xaa¿3?- Xaa¿4?- Xaa¿5?- Xaa¿6?- Xaa¿7?- Xaa¿8?- Xaa¿9?- Xaa¿10?- Xaa¿11? convenant pour l'inhibition de l'angiogénèse. L'invention concerne également des compositions inhibant l'angiogénèse et des procédés d'inhibition d'angiogénèse chez l'animal.

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