C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/241, 260/335
C07D 205/08 (2006.01) A61K 31/395 (2006.01) C07F 7/18 (2006.01) C07F 9/568 (2006.01)
Patent
CA 2005759
- 47 - DESCRIPTIVE ABSTRACT The invention relates to N-aryl-azetidinones, their preparation process and their use as active serine elastase inhibitors. The N-aryl-azetidinones are in accordance with formula: Image (I) in which R1 and R2 can be a halogen atom or an organic radical, R3 represents a halogen atom or another good starting group and R4 represents H or an organic radical. The compounds with R3=C1 or OSO2CH3, R4=H and Rl=R2=F or R1=F and R2=Br are irreversible and selective elastase inhibitors, B 9942 MDT
Joyeau Roger
Kobaiter Randa
Reboud Michele
Wakselman Michel
Centre National de La Recherche Scientifique (c.n.r.s.)
Goudreau Gage Dubuc
Joyeau Roger
Kobaiter Randa
Reboud Michele
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