N-benzyl-n'-phenyl- and phenalkyl-thioureas

Details N-benzyl-n'-phenyl- and phenalkyl-thioureas N-benzyl-n'-phenyl- and phenalkyl-thioureas

C - Chemistry, Metallurgy

07

C

C07C 335/12 (2006.01) A61K 31/17 (2006.01) A61K 31/195 (2006.01) C07C 335/20 (2006.01)

Patent

CA 2044797

700-0118 ABSTRACT Compounds of formula II Image (I) wherein one of R1 and R2 is branched lower alkyl and the other is hydrogen or branched lower alkyl, R3 is hydrogen or C1-4alkyl, R4 and R5 are hydrogen, halogen, C1-5alkyl, substituted C1-5alkyl, aryl, substituted or unsubstituted aryl or a group of formula, -COOH, -COOR8 or -CONR9R10, wherein R8 is C1-5alkyl and R8 and R10 are, independently, hydrogen or C1-5alkyl, R6 and R7 have the meanings given for R4 and R5 or, together with the carbon atom to which they are attached, form a substituted or unsubstituted C3-7cyclo- alkyl group, R is -O-, -S- or -NH- and X is -(CH2)n- wherein n is zero, 1, 2 or 3, and their physiologically hydrolysable and acceptable esters and amides and pharmaceutically acceptable salts thereof, processes for their production and pharmaceutical compositions comprising them.

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