N-benzylazolium derivatives

Details N-benzylazolium derivatives N-benzylazolium derivatives

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/41 (2006.01) A61K 31/495 (2006.01) A61K 31/675 (2006.01) C07D 233/64 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 417/00 (2006.01) C07D 521/00 (2006.01) C07F 9/6506 (2006.01) C07F 9/6518 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2214669

N-Benzylazolium derivatives of the general formula (I), (see fig.I) wherein Q is the remainder of an azole compound of the formula II (see fig.II) possessing antifungal activity; Z is nitrogen or methine; R1 and R2 are each independently a hydrogen atom or a group -OY [in which Y is a group easily hydrolyzable under physiological condition]; R3 and R4 are each independently a hydrogen or halogen atom, lower alkyl, lower alkoxy, lower alkylthio, (lower alkylcarbonyl)thiomethyl, carboxy or methoxycarbonyl; and X- is a pharmaceutically acceptable anion, as well as salts, hydrates or solvates of the compounds of the general formula (I) have antifungal properties.

Dérivés de N-benzylazolium de formule générale (I), (voir fig. I), où Q est le reste d'un azole de formule II (voir fig. II), ayant une activité antifongique; Z est de l'azote ou un méthine; R1 et R2 sont chacun indépendamment l'un de l'autre un atome d'hydrogène ou un groupe -OY [, Y étant un groupe facilement hydrolysable dans des conditions physiologiques; R3 et R4 sont chacun indépendamment l'un de l'autre un atome d'hydrogène ou d'halogène, un alkyle inf., un alcoxy inf., un alkylthio inf., un (alkylcarbonyle inf.)thiométhyle, un carboxy ou un méthoxycarbonyle; X- est un anion acceptable en pharmacie; sels, hydrates ou produits de solvatation de composés de formule générale (I), ayant des propriétés antifongiques.

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