C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/81 (2006.01) C07C 233/23 (2006.01) C07C 233/74 (2006.01) C07D 213/40 (2006.01)
Patent
CA 2673586
The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11.beta.-HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions.
L'invention concerne des composés de N-cyclohexyl benzamide et de benzène acétamide selon la formule (I) où R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p et q sont tels que définis dans la description; ainsi que des compositions pharmaceutiques les renfermant, des procédés d'utilisation des composés et des compositions de l'invention pour traiter des pathologies associées à des hydroxysteroïde déshydrogénases (p. ex. 11.beta.-HSD1), et l'utilisation de ces composés pour préparer des médicaments destinés au traitement de pathologies associées à des hydroxysteroïde déshydrogénases.
Han Nianhe
Liu Qingyian
Mcminn Dustin
Powers Jay
Yuan Chester C.
Amgen Inc.
Gowling Lafleur Henderson Llp
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