N-cyclopentyl modulators of chemokine receptor activity

Details N-cyclopentyl modulators of chemokine receptor activity N-cyclopentyl modulators of chemokine receptor activity

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61P 31/18 (2006.01) A61P 37/00 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2382880

The present invention is directed to compounds of formula (I) (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are use-ful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.

La présente invention concerne des composés représentés par la formule générale (I) dans laquelle R<1>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, X, n, x et y sont tels que définis dans la description. Ces composés, qui conviennent comme modulateurs de l'activité du récepteur de la chimiokine, conviennent plus particulièrement comme modulateurs des récepteurs CCR-5 et/ou CCR-3 de la chimiokine.

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