N-heterocyclic inhibitors of tnf-alpha expression

Details N-heterocyclic inhibitors of tnf-alpha expression N-heterocyclic inhibitors of tnf-alpha expression

C - Chemistry, Metallurgy

07

D

C07D 239/32 (2006.01) A61K 31/166 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61K 45/00 (2006.01) A61P 1/04 (2006.01) A61P 7/02 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/06 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43

Patent

CA 2451125

N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I). Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-a expression utilizing compounds of the present invention are also disclosed.

L'invention concerne des composés N-hétérocycliques bloquant la production de cytokines par inhibition de la kinase p38. Dans un mode de réalisation, les composés de la présente invention sont représentés par la formule (I). L'invention concerne également des méthodes de production correspondantes, des compositions pharmaceutiques et des méthodes de traitement d'états pathologiques associés à une activité kinase p38 ou une expression TNF-.alpha. inappropriée au moyen des composés de la présente invention.

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