C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/02 (2006.01) A61K 31/415 (2006.01) A61K 31/695 (2006.01) C07D 233/61 (2006.01) C07D 409/14 (2006.01) C07D 521/00 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2060940
ABSTRACT 1. The invention provides new imidazole containing alkoxyimino derivatives of tetrahydronaphthalene and chroman of general formula (I) Image I wherein Z is -CH2-or-O-; m is an integer of 1 to 4; n is zero or 1; T is a straight or branched, saturated-or unsaturated C1-C6 hydrocarbon chain, or a phenylene radical; is a bond or a divalent group consisting of-Si(R'R'')-; -O-CH2-, -CF2-,C(R'R'')-,vinylene or isopropenylene, wherein each of R' and R'' being the same or different is hydrogen or C1-C4 alkyl; R is hydrogen or C1-C4 alkyl; R1 and R2, being the same, are hydrogen or methyl, or one of R1 and R2 is hydrogen and the other is a) a C1-C6 alkyl group; b) a C5-C6 cycloalkyl or C5-C6 cycloalkyl-C1-C4 alkyl group, wherein the cycloalkyl group or moiety is unsubstituted or substituted by 1 to 4 C1-C4 alkyl groups; or Abstract 2. c) an aryl or aryl-C1-C4 alkyl group, wherein the aryl group or the aryl moiety is unsubstituted or substituted by 1 to 4 substituents independently chosen from halogen, hydroxy, C1-C4 alkyl, trihalo-C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio and C1-C4 alkylsulfonyl; R3 is hydrogen or a substituent chosen from halogen, hydroxy, C1-C4 alkyl, trihalo-C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio and C1-C4 alkylsulfonyl; R4 is an -OR5 or -N(R5 R6)group, wherein each of R5 and R6 independently is hydrogen, C1-C6 alkyl, phenyl or benzyl; and the pharmaceutically acceptable salts thereof, which are useful in the treatment of a disease state in which an anhancement of TxA2 synthesis exerts a pathogenic effect.
Cozzi Paolo
Ferti Corrado
Giordani Antonio
Rossi Arsenia
Salvati Patricia
Farmitalia Carlo Erba S.r.l.
Fetherstonhaugh & Co.
LandOfFree
N-imidazolyl derivatives of substituted alkoxyimino... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with N-imidazolyl derivatives of substituted alkoxyimino..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-imidazolyl derivatives of substituted alkoxyimino... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1594892