N-(ó-substituted-pyridinyl) carbonyl dipeptide...

Details N-(ó-substituted-pyridinyl) carbonyl dipeptide... N-(ó-substituted-pyridinyl) carbonyl dipeptide...

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2081471

A b s t r a c t Disclosed are dipeptide derivatives of general formula (I) (I) Image including tautomeric forms thereof, wherein: n is 0 or an integer of from 1 to 3; R is OH, SH, COOH, NH2, halogen, OR4, SR4, COOR4, NHR4 or N(R4)2, R4 being selected from lower alkyl, optionally substituted, aryl and acyl groups; R1 represents OH, lower alkoxy, optionally substituted, aryl lower alkoxy, aryloxy or disubstituted amino groups; R2 is selected from lower alkyl and amino lower alkyl groups; R3 represents halogen, NO2, lower alkyl, halo lower alkyl, aryl lower alkyl or aryl; and pharmaceutically acceptable salts thereof. Said derivatives are useful, among others, in the treatment of hypertension.

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