N-phenyl benzamide derivatives as sirtuin modulators

Details N-phenyl benzamide derivatives as sirtuin modulators N-phenyl benzamide derivatives as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/435 (2006.01) A61P 3/00 (2006.01) A61P 7/00 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) A61P 35/00 (2006.01) C07D 235/18 (2006.01) C07D 241/42 (2006.01) C07D 263/56 (2006.01) C07D 265/22 (2006.01) C07D 277/66 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2599989

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treatin and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

La présente invention décrit de nouveaux composés régulant la sirtuine ainsi que des méthodes d'emplois desdits composés. Lesdits composés régulant la sirtuine peuvent être employés dans le but d'augmenter la durée de vie d'une cellule, et dans le traitement prophylactique et/ou thérapeutique de nombreux maladies et troubles incluant, par exemple, les maladies ou les troubles liés à l~âge ou au stress, le diabète, l'obésité, les maladies neurodégénératives, les maladies cardio-vasculaires, les troubles de coagulation du sang, les inflammations, les cancers, et/ou les bouffées congestives de même que les maladies ou les troubles favorisés par une augmentation de l'activité des mitochondries. La présente invention décrit en outre des préparations comprenant un composé régulant la sirtuine en combinaison avec un autre agent thérapeutique.

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