N-phenyl-n'-cycloalkyl-alkenoyl piperazines and process for...

Details N-phenyl-n'-cycloalkyl-alkenoyl piperazines and process for... N-phenyl-n'-cycloalkyl-alkenoyl piperazines and process for...

C - Chemistry, Metallurgy

07

D

260/262, 260/266

C07D 295/18 (2006.01) C07D 213/74 (2006.01) C07D 239/42 (2006.01) C07D 241/20 (2006.01) C07D 295/185 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)

Patent

CA 1211435

ABSTRACT OF THE DISCLOSURE Pharmacologically active compounds are provided of the formula: Image I wherein R1 is a phenyl radical, pyridyl radical, a pyrimidyl group, or pyrazinyl radical, or a phenyl radical, pyridiyl radical, pyrimidyl radical, or pyrazinyl radical substituted by the radicals R3 and R4 which are the same or different and are hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxy, C1-C6-alkenyloxy groups, C3-C6-cycloalkyloxy groups, phenyl-C1-C4-alkoxy groups, C1-C6-alkylmercapto groups, the nitro group, the amino group, C1-C6-dialkylamino groups, C2-C6-alkanoyl groups, C2-C6-alkanoylamino groups, or C2-C6- alkanoyloxy groups and R2 is the adamantyl group, the 3,3- dimethyl-bicyclo[2.2.1] hept-2-yl radical, a saturated C3-C16- cycloalkenyl radical and alk is a straight or branched C1-C6 alkyl chain. The compounds of the invention are active pharmacologically or pharmacotherapeutically. For example, they are analgetically active. They possess a wide thera- peutic breadth and furthermore are characterized by the lack of central nervous system side effects such as for example, sedation and ataxia. The compound of the invention are centrally active analgetics.

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