N-phenyl piperidinylcamphorsulfonyl oxytocin antagonists

Details N-phenyl piperidinylcamphorsulfonyl oxytocin antagonists N-phenyl piperidinylcamphorsulfonyl oxytocin antagonists

C - Chemistry, Metallurgy

07

D

C07D 221/20 (2006.01) A61K 31/445 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 419/12 (2006.01) C07F 9/576 (2006.01)

Patent

CA 2055024

95/FPG53 96/FPG54 97/FPG55 98/FPG56 -i- 18241IA TITLE OF THE INVENTION PIPERIDINYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS ABSTRACT OF THE INVENTION Spirocyclic compounds of the formula: Image I 95/FPG53 - ii - 18241IA The compounds of formula I are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders. Also disclosed are pharma- ceutical compositions containing these compounds, methods of their use and methods of their preparation.

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