C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/228, 260/279
C07D 405/02 (2006.01) A61K 31/445 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/02 (2006.01) C07D 493/10 (2006.01)
Patent
CA 1300154
ABSTRACT OF THE DISCLOSURE Substituted benzamides of the general formula I I Image in which: R represents an alkoxy, alkenyloxy or alkynyloxy group containing up to 7 carbon atoms in the group, Rl is hydrogen or a NR4R5, or NR6COR7 group, where R4, R5 and R6, which may be the same or different, is each hydrogen or an alkyl group and R7 is an alkyl or trifluoromethyl group, R2 is hydrogen, halogen, or a nitro, or sulphamoyl group, R3 represents hydrogen or a methyl or methoxy group, X represents a hydrocarbon chain containing 1 to 4 carbon atoms, one of which may optionally be replaced by an oxygen atom, Y represents a non-aromatic cyclic ether or a non-aromatic - 2 - cyclic thioether group and pharmaceutically acceptable salts thereof are useful in the treatment of gastro-intestinal disorders. Various methods of synthesis are described including synthesis via novel amines of the formula Image III a which are themselves obtained by reduction of the corresponding oximes.
515257
Mauri Jacinto Moragues
Noguera Fernando Pujol
Noverola Armando Vega
Prieto Soto Jose Manuel
Spickett Robert Geoffrey William
Fordonal S.a.
Hirons Brown & Orange
Mauri Jacinto Moragues
Noguera Fernando Pujol
Noverola Armando Vega
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