N-terminal modifications of rantes and methods of use

Details N-terminal modifications of rantes and methods of use N-terminal modifications of rantes and methods of use

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/19 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2300046

N-terminally modified RANTES derivatives are disclosed. The derivatives effectively block the inflammatory effects of RANTES, and are useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, and rheumatoid arthritis. Additionally, the compounds are useful for the treatment of HIV infection.

L'invention concerne des dérivés de la protéine RANTES, à modification N-terminale. Ces dérivés bloquent de manière efficace les effets inflammatoires de la protéine RANTES et ils sont donc utiles dans le traitement de l'asthme, de la rhinite allergie, de l'eczéma constitutionnel, de l'athérome/athérosclérose et de la polyarthrite rhumatoïde. En outre, ces composés sont utiles dans le traitement de l'infection à VIH.

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