N6 heterocyclic substituted adenosine derivatives

Details N6 heterocyclic substituted adenosine derivatives N6 heterocyclic substituted adenosine derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/70 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2264155

A substituted N6-oxa, thia, thioxa and azacycloalkyl substituted adenosine derivative of formula (I) and a method for using the composition as an A1 heart adenosine receptor. In said formula, R1 is a monocyclic or polycyclic heterocyclic group containing from 3 to 15 atoms, at least one of which is selected from the group consisting of N, O, P and S-(O)o-2 and wherein R1 does not contain an epoxide group.

On décrit un dérivé d'adénosine à substitution N?6¿-oxa, thia, thioxa et azacycloalkyle, répondant à la formule (I), ainsi qu'un procédé d'utilisation de cette composition en tant qu'agoniste du récepteur de type I de l'adénosine cardiaque (A¿1?). Dans cette formule, R¿1? représente un groupe hétérocyclique, monocyclique ou polycyclique contenant 3 à 15 atomes, dont l'un au moins est choisi dans le groupe constitué par N, O, P et S-(O)¿o-2?, R¿1? ne contenant pas de groupe époxyde.

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