C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/52 (2006.01) A61K 31/194 (2006.01) C07C 319/02 (2006.01)
Patent
CA 2337797
The present invention relates to N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy.
L'invention concerne des inhibiteurs de l'activité enzymatique dipeptidase acide N-acétylée à liaison alpha (NAALADase), des compositions pharmaceutiques renfermant ces inhibiteurs, et des procédés relatifs à leur utilisation pour inhiber ladite activité enzymatique. Par cette inhibition, on peut mener des activités neuronales, inhiber l'angiogenèse et traiter les anomalies liées au glutamate, les troubles compulsifs, les maladies de la prostate, la douleur et la neuropathie diabétique.
Jackson Paul F.
Lapidus Rena S.
Maclin Keith M.
Majer Pavel
Slusher Barbara S.
Eisai Inc.
Guilford Pharmaceuticals Inc.
Smart & Biggar
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