Near infrared fluorescent contrast agent and fluorescence...

Details Near infrared fluorescent contrast agent and fluorescence... Near infrared fluorescent contrast agent and fluorescence...

A - Human Necessities

61

K

A61K 49/00 (2006.01)

Patent

CA 2394539

A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.

L'invention concerne un agent de contraste fluorescent proche infrarouge renfermant un composé doté d'au moins trois groupes d'acide sulfonique dans une molécule et un procédé d'imagerie par fluorescence consistant à introduire ledit agent de contraste de cette invention dans un corps en vie, exposer le corps à une lumière d'excitation, et détecter la fluorescence proche infrarouge émanant de l'agent de contraste. Cet agent de contraste fluorescent proche infrarouge de ladite invention est excité par une lumière d'excitation et émet une fluorescence proche infrarouge. Cette fluorescence infrarouge possède une meilleure transmission à travers des tissus biologiques. Ainsi on rend possible la détection de lésions dans la région peu apparente d'un corps en vie. De plus, ledit agent de contraste présente une solubilité plus grande dans l'eau et une toxicité plus faible et peut, de ce fait, être utilisé sans danger.

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