A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/095 (2006.01) A61K 39/102 (2006.01) C07K 14/22 (2006.01)
Patent
CA 2493092
The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
La présente invention concerne des compositions immunogènes et des vaccins destinés au traitement ou à la prévention de la maladie à Neisseria. Des compositions immunogènes de l'invention contiennent des combinaisons d'antigènes choisies à partir d'au moins deux classes différentes d'antigènes comprenant des adhésines, de protéines de la famille des autotransporteurs, des toxines, des protéines d'acquisition du fer et des protéines associées aux membranes (de préférence une (des) protéine(s) extrinsèque(s) externe(s)). De telles combinaisons d'antigènes peuvent cibler la réponse immunitaire contre différents aspects du cycle de vie de Neisseria, d'où une réponse immunitaire plus efficace.
Berthet Francois-Xavier Jacques
Biemans Ralph
Denoel Philippe
Feron Christiane
Goraj Carine
Glaxosmithkline Biologicals S.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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