C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/81 (2006.01)
Patent
CA 2202351
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
L'invention se rapporte à des protéines agissant comme anticoagulants et/ou comme inhibiteurs de la sérine-protéase et qui comprennent au moins un domaine des Protéines Anticoagulantes extraites des Nématodes (NAP). Certaines de ces protéines présentent une activité inhibitrice du facteur Xa, et d'autres agissent comme inhibiteurs du facteur VIIa/TF. Ces protéines peuvent être isolées de sources naturelles, telles que les nématodes, synthétisées chimiquement ou obtenues par des procédés de recombinaison utilisant divers systèmes d'expression de l'ADN.
Bergum Peter W.
Gansemans Yannick Georges Jozef
Jespers Laurent Stephane
Laroche Yves Rene
Lauwereys Marc Josef
Corvas International Inc.
Dendreon Corporation
Smart & Biggar
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