Neuropilin-1 inhibitors

Details Neuropilin-1 inhibitors Neuropilin-1 inhibitors

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 15/79 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2510859

The present invention relates to molecules interfering with the function of neuropilin-1 in the context of angiogenesis and the treatment of cancer. Molecules, polypeptides, antibodies, compositions and methods are provided that are useful for reducing, inhibiting or treating angiogenesis, the invasion of blood vessels into tumors, and/or the invasion or the metastatic potential of specific tumor cells. Additionally, a method is provided that allows identifying molecules, which interfere with the functionality of neuropilin-1. Furthermore, a method is provided that allows determining whether a naturally occuring tumor cell depends on functional neuropilin-1 for its invasiveness and/or metastatic potential.

La présente invention concerne des molécules présentant des interférences avec les fonctions de la neuropiline-1 dans le contexte de l'angiogenèse et du traitement du cancer. L'invention concerne ainsi des molécules, des polypeptides, des anticorps, des compositions et des procédés convenant pour réduire, inhiber ou traiter l'angiogenèse, l'invasion tumorale des vaisseaux sanguins et/ou l'invasion par de cellules tumorales spécifiques ou leur potentiel métastatique. L'invention concerne en outre un procédé permettant d'identifier des molécules qui interfèrent avec la fonctionnalité de la neuropiline-1. L'invention concerne enfin un procédé qui permet de déterminer si une cellule tumorale apparaissant naturellement dépend de la neuropiline-1 fonctionnelle pour son caractère invasif et/ou son potentiel métastatique.

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