C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/12 (2006.01) A61K 31/42 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2335190
The invention relates to new 2-aminocarbonyl-5(2H)-isoxazolones used as selective ligands of a high-affinity binding site of diisopropyl- fluorophosphate (DFP) on brain membranes, for prophylaxis and treatment of diseases of the central nervous system, especially cognitive disorders, depression, schizophrenia and anxiety.
Nouvelles 2-aminocarbonyl-5(2H)-isoxazolones en tant que ligands sélectifs d'un site de liaison à haute affinité de diisopropyl-fluorophosphate (DFP) sur des membranes du cerveau pour la prophylaxie et le traitement de maladies du système nerveux central, en particulier les troubles cognitifs, la dépression, la schizophrénie et l'angoisse.
Boss Frank
Erguden Jens
Furstner Chantal
Lensky Stephan
Riedl Bernd
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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