New arylpiperazinyl compounds

Details New arylpiperazinyl compounds New arylpiperazinyl compounds

C - Chemistry, Metallurgy

07

D

C07D 295/13 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61P 15/00 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2513915

The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by formula (I), and synthesis and uses thereof for treating diseases including those mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as generalized anxiety disorder, ADD/ADHD, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

L'invention concerne des agonistes ou des antagonistes du récepteur 5-HT. L'invention concerne également de nouveaux composés de sulfonamide d'arylpipérazinyle représentés par la formule (I), leur synthèse et leur utilisation pour traiter des maladies induites directement ou indirectement par les récepteurs 5-HT. Ces états pathologiques comprennent les troubles du système nerveux central tels les troubles d'anxiété généralisée, ADD/ADHD, les blessures neurales, les accidents cérébro-vasculaires et les migraines. L'invention concerne enfin des procédés de préparation, de nouveaux intermédiaires et des sels pharmaceutiques de ceux-ci.

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