New benzamides as ppar.gamma. modulators

Details New benzamides as ppar.gamma. modulators New benzamides as ppar.gamma. modulators

C - Chemistry, Metallurgy

07

C

C07C 235/52 (2006.01) A61K 31/166 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/435 (2006.01) A61K 31/498 (2006.01) A61P 5/00 (2006.01) C07D 209/04 (2006.01) C07D 213/02 (2006.01) C07D 241/40 (2006.01) C07D 333/08 (2006.01)

Patent

CA 2528231

Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-~position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- ~and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPAR~ and PPAR~/ PPAR.delta. modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.

Composés de structure générale (I) dans laquelle le noyau benzène central peut être substitué dans la position meta ou para, A représente hydroxyle, alcoxyle, hydroxylamine, alcoxylamine ou un radical amine éventuellement substitués, W représente un biradical à liaison N et C choisi parmi plusieurs possibilités et Z représente un radical carbone choisi parmi plusieurs possibilité. Ces composés sont des modulateurs de PPAR.gamma. et de PPAR.gamma. / PPARd et sont par conséquent utiles pour prévenir et / ou traiter un état pathologique ou une maladie médiés par ces récepteurs.

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