New carboxylic acids and the esters thereof, pharmaceutical...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/80 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 243/02 (2006.01) C07D 249/08 (2006.01) C07D 285/36 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2513132

The invention relates to carboxylic acids and esters of a general formula (I), wherein Ar, R, R1, X1, X3, X4, Y and Y1 have a definition given in a claim 1. Said invention also relates to tautomers, the enantiomers, mixtures and salts thereof, in particular to physiologically compatible salts containing organic or inorganic acids or bases, drugs containing said compounds using them as CGRT antagonists for treating a headache and to method for the production and use thereof for producing and cleaning antibodies and as labelled compounds for RIA and ELISA biological dosages and, finally as auxiliary diagnostics or analytics for neutrotransmitters.

La présente invention concerne des acides carboxyliques et esters de la formule générale (I), où Ar, R, R?1¿, X?1¿, X?3¿, X?4¿, Y et Y?1¿ ont la définition donnée dans la revendication 1. L'invention concerne également leurs tautomères, leurs diastéréomères, leurs énantiomères, leurs mélanges et leurs sels, notamment les sels physiologiquement compatibles contenant des acides ou bases inorganiques ou organiques, les médicaments contenant ces composés, leur utilisation comme antagonistes de CGRP pour traiter les maux de tête et leur procédé de production ainsi que leur utilisation pour produire et épurer les anticorps et comme composés marqués dans les dosages biologiques RIA et ELISA et enfin comme auxiliaires diagnostiques ou analytiques dans la recherche des neutrotransmetteurs.

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