C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/16 (2006.01) A61K 31/195 (2006.01) A61K 31/34 (2006.01) A61K 38/15 (2006.01) C07C 237/22 (2006.01) C07D 273/00 (2006.01) C07D 307/20 (2006.01) C07D 413/06 (2006.01) C07K 5/023 (2006.01) C07K 11/00 (2006.01) C12P 13/04 (2006.01) C12P 17/04 (2006.01) C12P 17/14 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2179490
The present invention provides novel cryptophycin compounds having structure (I). The present invention also provides methods for producing cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided by the present invention, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. The present invention further provides methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.
La présente invention se rapporte à de nouveaux composés de cryptophycines ayant la structure (I). La présente invention se rapporte également à des procédés de production de cryptophycines à partir de Nostoc sp. des algues bleues (cyanobactéries), à des compositions pharmaceutiques comprenant ces nouvelles cryptophycines, ainsi qu'à des procédés d'utilisation de ces cryptophycines destinés à inhiber la prolifération des cellules hyperprolifératives. La présente invention se rapporte, en outre, à des procédés d'utilisation des crytophycines destinés à inhiber la prolifération des cellules hyperprolifératives comportant des phénotypes résistants aux médicaments, et à traiter des états pathologiques tels que la néoplasie.
Corbett Thomas H.
Golakoti Trimurtulu
Mooberry Susan L.
Moore Richard E.
Patterson Gregory M. L.
Sim & Mcburney
University Of Hawai'i
Wayne State University
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