C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/437 (2006.01) A61K 31/506 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2664115
The invention relates to new products of the formula (I) in which: Het is an optionally substituted mono- or bicyclic heterocycle containing 1 to 4 heteroatoms selected from N, O or S; R1 is X-(A-B)n-CONH2, X-(A-B)n-O-CONH2, X-(A-B)n-NH-CONH2, X-(CH2)m-heterocycloalkyl, X-(CH2)m-aryl and X-(CH2)m-heteroaryl with X being -O-C(O), -NH-C(O), NH-CS, -NH-CO-CH2-O-; -NH-CO-CH2-S-CH2-CO-NH-; -NH-CO-(CH2)2-SO2-; -NH-CO-CH2-N(CH3)-CO-; A and B represent a simple bond, CH2, CH-alkyl, CH-aralkyl, n = 1,2 and m = 0, 1; R2 and R'2 represent H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, carboxy free or esterified by an alkyl, carboxamide, CO-NH(alkyl) and NH-CO-alkyl radical; p= 1 to 4 and p'= 1 to 3; L represents a simple bond, CH2, C(O), O, S or NH, all said radicals being optionally substituted. The invention also relates to all the isomeric forms of the products and the salts thereof used as drugs.
L'invention concerne les nouveaux produits de formule (I), dans lesquels Het représente un hétérocycle mono ou bicyclique, de 1 à 4 hétéroatomes choisis parmi N, O ou S, éventuellement substitué; R1 représente X-(A-B)n-CONH2, X-(A-B)n-O-CONH2, X-(A-B)n-NH-CONH2, X-(CH2)m-hétérocycloalkyle, X-(CH2)m-aryle et X-(CH2)m-hétéroaryle avec X représente -O-C(O), -NH-C(O), NH-CS, -NH-CO-CH2-O-; -NH-CO-CH2-S-CH2-CO-NH-; -NH-CO-(CH2)2-SO2-; -NH-CO-CH2-N(CH3)-CO-; A et B représentent simple liaison, CH2, CH-alkyle, CH-aralkyle, n = 1,2 et m = 0, 1; R2 et R'2 représente H, halogène, CF3, nitro, cyano, alkyle, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, carboxy libre ou estérifié par un radical alkyle, carboxamide, CO-NH(alkyl) et NH-CO-alkyl; p= 1 à 4 et p'= 1 à 3; L représente simple liaison, CH2, C(O), O, S ou NH, tous ces radicaux étant éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.
Bertin Luc
Goulaouic Helene
Hamley Peter
Hourcade Stephane
Mailliet Patrick
Robic
Sanofi-Aventis
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