New process

Details New process New process

C - Chemistry, Metallurgy

07

D

C07D 207/26 (2006.01) C07C 223/02 (2006.01) C07C 227/02 (2006.01) C07C 227/16 (2006.01) C07C 227/22 (2006.01) C07C 229/34 (2006.01) C07C 231/10 (2006.01) C07D 207/263 (2006.01) C07D 207/38 (2006.01) C07D 207/44 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2674291

The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.

Cette invention concerne des pyrrolidin-2-ones représentés par la formule (1) ou des sels de ceux-ci, dans laquelle R1 représente hydrogène ou un groupe protecteur d'azote. L'invention concerne également des procédés permettant de les préparer et de les utiliser pour la préparation d'inhibiteurs NEP, plus particulièrement pour la préparation d'un ester éthylique d'acide butanoïque N-(3-carboxyl-1 -oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl ou un sel de celui-ci.

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